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CS-W001157 4
Total: USD 88.00

1-(2,5-Difluorophenyl)ethanone

  • CAS No. 1979-36-8

  • Cat. No. CS-W010921
  • Purity≥98%
  • MDL No.MFCD00009898

*For research and further manufacturing use only, not for direct human use.

1-(2,5-Difluorophenyl)ethanone|CS-W010921

Structure of 1979-36-8

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General Information

  • CAS No. 1979-36-8
  • Cat. No. CS-W010921
  • Purity ≥98%
  • MDL No. MFCD00009898
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₂O
  • Molecular Weight 156.13
  • Synonym(s) 2',5'-Difluoroacetophenone
  • SMILES CC(C1=CC(F)=CC=C1F)=O

Description

1-(2,5-Difluorophenyl)ethanone features a fluorinated aromatic ring paired with a reactive ketone group, enabling direct incorporation into pharmaceutical intermediates. The ortho- and para-fluoro substituents enhance metabolic stability and influence electronic properties for targeted synthetic transformations. This bench-stable compound serves as a key building block in medicinal chemistry campaigns requiring electron-deficient aryl ketones.

Application

1-(2,5-Difluorophenyl)ethanone serves as a versatile aryl ketone building block for medicinal chemistry and materials synthesis. Its difluorophenyl moiety enhances metabolic stability and modulates electronic properties, while the acetyl group enables standard transformations including nucleophilic addition, reduction, and coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in Friedel-Crafts acylation, Grignard additions, and transition-metal-catalyzed cross-couplings.

Synthesis

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    • In-stock
      1-(2,5-Difluorophenyl)ethanone|CS-W010921
      1979-36-8

    References

    • Journal of Organic Chemistry, , vol. 26, p. 919 - 923
  • Route2

    References

    • Russian Journal of Organic Chemistry, , vol. 39, # 11 p. 1581 - 1586

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.1674
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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