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CS-W001157 4
Total: USD 88.00

3-(4-Methoxyphenyl)piperidine

  • CAS No. 19725-26-9

  • Cat. No. CS-0449151
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(4-Methoxyphenyl)piperidine|CS-0449151

Structure of 19725-26-9

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General Information

  • CAS No. 19725-26-9
  • Cat. No. CS-0449151
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO
  • Molecular Weight 191.27
  • Synonym(s) None
  • SMILES COC1=CC=C(C=C1)C2CCCNC2

Description

3-(4-Methoxyphenyl)piperidine is a bench-stable, electron-rich piperidine derivative featuring a para-methoxyaryl substituent that enhances solubility and metabolic stability. This structural motif integrates readily into bioactive scaffolds, enabling efficient access to ligands for CNS-targeted drug discovery.

Application

3-(4-Methoxyphenyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization at the piperidine nitrogen and aromatic ring. Its bench-stable nature, combined with favorable solubility and compatibility with common coupling reactions, facilitates efficient synthesis of CNS-targeted compounds and API intermediates.

Synthesis

  • Route1
    • 3-(4-Methoxyphenyl)pyridine|CS-0150405
      5958-02-1
    • ~%
    • In-stock
      3-(4-Methoxyphenyl)piperidine|CS-0449151
      19725-26-9

    References

    • Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482
  • Route2
    • null|null
      19724-82-4
    • ~97%
    • In-stock
      3-(4-Methoxyphenyl)piperidine|CS-0449151
      19725-26-9

    References

    • Kanao; Hashizume; Ichikawa; Irie; Satoh; Isoda Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 180 - 188
  • Route3

    References

    • Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G. Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.1622
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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