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CS-W001157 4
Total: USD 88.00

3-(3-Fluorophenyl)prop-2-yn-1-ol

  • CAS No. 197239-54-6

  • Cat. No. CS-0156913
  • Purity≥95%
  • MDL No.MFCD04039231

*For research and further manufacturing use only, not for direct human use.

3-(3-Fluorophenyl)prop-2-yn-1-ol|CS-0156913

Structure of 197239-54-6

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General Information

  • CAS No. 197239-54-6
  • Cat. No. CS-0156913
  • Purity ≥95%
  • MDL No. MFCD04039231
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇FO
  • Molecular Weight 150.15
  • Synonym(s) 3-(3-FLUORO-PHENYL)-PROP-2-YN-1-OL
  • SMILES C1=CC(=CC(=C1)F)C#CCO

Description

3-(3-Fluorophenyl)prop-2-yn-1-ol features a conjugated alkyne tethered to a fluorinated phenyl ring, enabling efficient coupling in transition-metal-catalyzed transformations. The terminal alkyne and primary alcohol functionalities facilitate diverse downstream modifications. This compound exhibits excellent stability under standard conditions and integrates readily into complex molecular architectures.

Application

3-(3-Fluorophenyl)prop-2-yn-1-ol serves as a versatile synthetic building block for the construction of functionalized aryl alkynes, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. Its terminal alkyne functionality exhibits high reactivity in click chemistry applications, while the ortho-fluorophenyl moiety provides enhanced metabolic stability and favorable electronic properties. The molecule demonstrates excellent bench stability and compatibility with common protecting groups, facilitating straightforward purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.1695
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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