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CS-W001157 4
Total: USD 88.00

2-[4-Fluoro-2-(trifluoromethyl)phenyl]acetic acid

  • CAS No. 195447-80-4

  • Cat. No. CS-0060424
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[4-Fluoro-2-(trifluoromethyl)phenyl]acetic acid|CS-0060424

Structure of 195447-80-4

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General Information

  • CAS No. 195447-80-4
  • Cat. No. CS-0060424
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆F₄O₂
  • Molecular Weight 222.14
  • Synonym(s) 4-Fluoro-2-(trifluoromethyl)phenylacetic acid
  • SMILES C1=CC(=CC(=C1CC(=O)O)C(F)(F)F)F

Description

This fluorinated arylacetic acid features a trifluoromethyl group enhancing electron withdrawal and metabolic stability. The 4-fluoro substitution further modulates electronic properties, enabling precise tuning in medicinal chemistry applications. Designed for integration into bioactive scaffolds, it delivers robust performance under standard conditions.

Application

2-[4-Fluoro-2-(trifluoromethyl)phenyl]acetic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard amide and ester transformations. Its trifluoromethyl and fluoro substituents enhance metabolic stability and membrane permeability. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.4716
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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