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CS-W001157 4
Total: USD 88.00

4-Chloro-2-fluorophenylacetic acid

  • CAS No. 194240-75-0

  • Cat. No. CS-W008132
  • Purity≥98%
  • MDL No.MFCD03095402

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-fluorophenylacetic acid|CS-W008132

Structure of 194240-75-0

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General Information

  • CAS No. 194240-75-0
  • Cat. No. CS-W008132
  • Purity ≥98%
  • MDL No. MFCD03095402
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆ClFO₂
  • Molecular Weight 188.58
  • Synonym(s) 4-Chlor-2-Flour phenyactic acid
  • SMILES OC(=O)CC1=C(F)C=C(Cl)C=C1

Description

4-Chloro-2-fluorophenylacetic acid features a strategically positioned chloro and fluoro substituent on the phenyl ring, enhancing electronic effects and metabolic stability. This electron-deficient aryl moiety integrates readily into bioactive scaffolds, offering improved binding affinity in medicinal chemistry applications. The carboxylic acid group enables direct conjugation or derivatization under standard conditions.

Application

4-Chloro-2-fluorophenylacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard coupling and functionalization reactions. Its electron-withdrawing halogen substituents enhance metabolic stability and modulate electronic properties. The carboxylic acid group facilitates direct derivatization or incorporation into peptide and heterocyclic scaffolds, offering excellent bench stability and compatibility with common purification methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1062
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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