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CS-W001157 4
Total: USD 88.00

4-Hydroxytetrahydro-2H-thiopyran 1,1-dioxide

  • CAS No. 194152-05-1

  • Cat. No. CS-W005199
  • Purity≥97%
  • MDL No.MFCD12152579

*For research and further manufacturing use only, not for direct human use.

4-Hydroxytetrahydro-2H-thiopyran 1,1-dioxide|CS-W005199

Structure of 194152-05-1

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General Information

  • CAS No. 194152-05-1
  • Cat. No. CS-W005199
  • Purity ≥97%
  • MDL No. MFCD12152579
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀O₃S
  • Molecular Weight 150.20
  • Synonym(s) Tetrahydro-2H-thiopyran-4-ol 1,1-dioxide AldrichCPR
  • SMILES OC1CCS(=O)(=O)CC1

Description

4-Hydroxytetrahydro-2H-thiopyran 1,1-dioxide features a hydroxyl group at the 4-position of a saturated thiopyran ring, with a sulfonyl moiety at the 1-position conferring high polarity and moisture tolerance. This bench-stable scaffold integrates readily into bioactive molecule synthesis, offering a versatile handle for derivatization in medicinal chemistry and materials science applications.

Application

4-Hydroxytetrahydro-2H-thiopyran 1,1-dioxide serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to sulfonated heterocyclic scaffolds. Its hydroxyl group facilitates selective derivatization, while the sulfone moiety enhances polarity and metabolic stability. The compound exhibits excellent bench stability and compatibility with standard coupling and protection protocols, making it well-suited for modular synthesis of bioactive molecules.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 73, p. 2473,2478
  • Route2

    References

    • Roelle, Thomas; Grubbs, Robert H. Chemical Communications (Cambridge, United Kingdom), 2002 , # 10 p. 1070 - 1071
  • Route3

    References

    • Chemical Communications (Cambridge, United Kingdom), , # 10 p. 1070 - 1071

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   -0.4441
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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