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Structure of 1935958-72-7
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2-Iodo-4-nitro-1H-indole features a sterically accessible indole core functionalized with iodine at C2 and a nitro group at C4, enabling direct participation in palladium-catalyzed cross-coupling reactions. The electron-deficient aryl iodide facilitates efficient coupling under mild conditions, while the para-nitro substitution enhances reactivity and stability. This compound serves as a key building block for advanced heterocyclic architectures in medicinal chemistry and materials science.
2-Iodo-4-nitro-1H-indole serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation under standard conditions. The iodine handle provides high reactivity in palladium-catalyzed coupling protocols, while the 4-nitro group enhances electrophilicity for nucleophilic substitution and facilitates further functionalization. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis of complex indole-based scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: