2-(Dimethylamino)-6-fluoronicotinaldehyde

Name: 2-(Dimethylamino)-6-fluoronicotinaldehyde
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CAS No. 193481-62-8
Cat. No. CS-0378254
Purity≥98%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-(Dimethylamino)-6-fluoronicotinaldehyde|CS-0378254

Structure of 193481-62-8

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General Information

CAS No. 193481-62-8
Cat. No. CS-0378254
Purity ≥98%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₉FN₂O
Molecular Weight 168.17
Synonym(s) 3-Pyridinecarboxaldehyde, 2-(dimethylamino)-6-fluoro-
SMILES O=CC1=CC=C(N=C1N(C)C)F

Description

2-(Dimethylamino)-6-fluoronicotinaldehyde features a fluorinated pyridine core paired with a dimethylamino group, delivering enhanced electron density at the para-position. This combination enables efficient coupling in transition-metal-catalyzed transformations and facilitates rapid conjugation in bioconjugate chemistry. The aldehyde functionality provides direct reactivity for imine formation and oxime ligation, supported by bench-stable handling under standard conditions.

Application

2-(Dimethylamino)-6-fluoronicotinaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated heterocycles and bioactive scaffolds. Its electron-rich dimethylamino group enhances reactivity in nucleophilic additions, while the aldehyde functionality facilitates imine formation and condensation reactions. Bench-stable and compatible with standard purification methods, it functions effectively in multistep syntheses requiring functional group tolerance and predictable regiochemistry.

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

TPSA 33.2
LogP 1.0992
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-(Dimethylamino)-6-fluoronicotinaldehyde

CAS No. 193481-62-8

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