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2-Fluoro-6-methyl-3-nitropyridine

  • CAS No. 19346-45-3

  • Cat. No. CS-0007516
  • Purity≥95%
  • MDL No.MFCD03095067

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-methyl-3-nitropyridine|CS-0007516

Structure of 19346-45-3

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General Information

  • CAS No. 19346-45-3
  • Cat. No. CS-0007516
  • Purity ≥95%
  • MDL No. MFCD03095067
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O₂
  • Molecular Weight 156.11
  • Synonym(s) 2-FLUORO-3-NITRO-6-PICOLINE
  • SMILES O=[N+](C1=CC=C(C)N=C1F)[O-]

Description

2-Fluoro-6-methyl-3-nitropyridine features a trifunctional pyridine core with electron-withdrawing nitro and fluoro groups paired with an electron-donating methyl substituent. This electronic asymmetry enables selective functionalization in cross-coupling reactions, particularly in the development of fluorinated heterocyclic scaffolds for medicinal chemistry applications.

Application

2-Fluoro-6-methyl-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization at the pyridine ring due to orthogonal electronic activation by the nitro and fluorine substituents. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient access to substituted heterocycles. The methyl group provides a handle for further derivatization, while the nitro function supports reduction to an amine or conversion into other nitrogen-containing scaffolds common in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.43732
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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