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Ethyl 2-amino-3,3,3-trifluoropropanoate hydrochloride

  • CAS No. 193140-71-5

  • Cat. No. CS-0128342
  • Molecule weight207.58
  • Purity≥97%
  • MDL No.MFCD14525479

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-amino-3,3,3-trifluoropropanoate hydrochloride|CS-0128342

Structure of 193140-71-5

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General Information

  • CAS No. 193140-71-5
  • Cat. No. CS-0128342
  • Purity ≥97%
  • MDL No. MFCD14525479
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉ClF₃NO₂
  • Molecular Weight 207.58
  • Synonym(s) Ethyl 2-amino-3,3,3-trifluoropropionate hydrochloride
  • SMILES O=C(OCC)C(N)C(F)(F)F.Cl

Description

Ethyl 2-amino-3,3,3-trifluoropropanoate hydrochloride features a trifluoromethyl group that enhances metabolic stability and lipophilicity. The amine functionality enables direct derivatization, while the ethyl ester serves as a handle for subsequent transformations. This bench-stable salt form improves solubility and handling in synthetic workflows.

Application

Ethyl 2-amino-3,3,3-trifluoropropanoate hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated bioactive scaffolds. The trifluoromethyl group imparts metabolic stability and enhanced lipophilicity, while the amino and ester functionalities offer orthogonal reactivity for peptide coupling, amidation, or heterocycle formation. Bench-stable and readily purified by standard techniques, it functions effectively in multi-step syntheses requiring robust functional group tolerance.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P338-P362-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.8609
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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