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CS-W001157 4
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8-Methyl-1-naphthoic acid

  • CAS No. 19310-98-6

  • Cat. No. CS-0139690
  • Molecule weight186.21
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

8-Methyl-1-naphthoic acid|CS-0139690

Structure of 19310-98-6

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General Information

  • CAS No. 19310-98-6
  • Cat. No. CS-0139690
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀O₂
  • Molecular Weight 186.21
  • Synonym(s) 8-Methyl-naphthoesaeure-(1)
  • SMILES CC1=CC=CC2=CC=CC(C(O)=O)=C21

Description

8-Methyl-1-naphthoic acid features a methyl group at the 8-position of the naphthoic acid scaffold, enhancing steric and electronic properties. This substitution imparts improved solubility and stability under standard bench conditions, facilitating its use in synthetic routes requiring robust aromatic carboxylic acids. The molecule serves as a key building block in pharmaceutical intermediates and functional materials.

Application

8-Methyl-1-naphthoic acid serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the naphthalene core for pharmaceutical and materials applications. Its carboxylic acid group facilitates coupling reactions, while the methyl substituent provides steric and electronic modulation. The compound exhibits good bench stability, simplifies purification, and functions effectively in standard esterification, amide formation, and metal-catalyzed cross-coupling protocols.

Synthesis

  • Route1
    • 8-Formyl-1-naphthoic acid|CS-W015625
      5811-87-0
    • ~%
    • In-stock
      8-Methyl-1-naphthoic acid|CS-0139690
      19310-98-6

    References

    • Journal of the American Chemical Society, , vol. 71, p. 1870
  • Route2
    • null|null
      81-84-5
    • ~%
    • In-stock
      8-Methyl-1-naphthoic acid|CS-0139690
      19310-98-6

    References

    • Journal of Organic Chemistry, , vol. 15, p. 608,614, 615
  • Route3
    • In-stock
      8-Bromo-1-naphthoic acid|CS-W014098
      1729-99-3
    • null|null
      74-88-4
    • ~%
    • In-stock
      8-Methyl-1-naphthoic acid|CS-0139690
      19310-98-6

    References

    • Journal of Organic Chemistry, , vol. 50, # 19 p. 3522 - 3526

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.84642
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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