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2-(Bromomethyl)-2-(hydroxymethyl)propane-1,3-diol

  • CAS No. 19184-65-7

  • Cat. No. CS-0079598
  • Purity≥97%
  • MDL No.MFCD00135306

*For research and further manufacturing use only, not for direct human use.

2-(Bromomethyl)-2-(hydroxymethyl)propane-1,3-diol|CS-0079598

Structure of 19184-65-7

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General Information

  • CAS No. 19184-65-7
  • Cat. No. CS-0079598
  • Purity ≥97%
  • MDL No. MFCD00135306
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁BrO₃
  • Molecular Weight 199.04
  • Synonym(s) 1,3-Propanediol, 2-(bromomethyl)-2-(hydroxymethyl)-
  • SMILES OCC(CO)(CBr)CO

Description

This trifunctional diol features a bromomethyl group and two hydroxymethyl substituents, enabling selective derivatization in synthetic workflows. The pendant bromide facilitates nucleophilic substitution, while the hydrophilic hydroxyls enhance solubility and compatibility with aqueous reaction systems. Designed for use in polymer conjugation, bioconjugate synthesis, and functional material development under standard conditions.

Application

2-(Bromomethyl)-2-(hydroxymethyl)propane-1,3-diol serves as a versatile diol-containing building block for the synthesis of functionalized heterocycles and glycoconjugates. Its bifunctional reactivity—combining a primary bromide and two hydroxyl groups—enables selective derivatization under mild conditions. The molecule exhibits good bench stability and facilitates efficient purification via crystallization or chromatography, making it well-suited for iterative synthetic sequences in medicinal chemistry and carbohydrate chemistry applications.

Synthesis

  • Route1
    • null|null
      115-77-5
    • ~51%
    • In-stock
      2-(Bromomethyl)-2-(hydroxymethyl)propane-1,3-diol|CS-0079598
      19184-65-7

    References

    • ISIS Pharma GmbH Patent: US6180664 B2, 2001 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.6554
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   4

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