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3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

  • CAS No. 191732-74-8

  • Cat. No. CS-0368917
  • Molecule weight259.26
  • Purity≥98%
  • MDL No.MFCD31692699

*For research and further manufacturing use only, not for direct human use.

3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione|CS-0368917

Structure of 191732-74-8

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General Information

  • CAS No. 191732-74-8
  • Cat. No. CS-0368917
  • Purity ≥98%
  • MDL No. MFCD31692699
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₃N₃O₃
  • Molecular Weight 259.26
  • Synonym(s) None
  • SMILES O=C(C(N(CC1=C2C=C(N)C=C1)C2=O)CC3)NC3=O

Description

This piperidine-2,6-dione scaffold integrates a 6-amino-1-oxoisoindolin-2-yl group, delivering a rigid, electron-deficient core ideal for conjugation in bioactive molecule design. The pendant amine enables direct functionalization, while the diketone moiety supports derivatization under mild conditions. Bench-stable and moisture-tolerant, it streamlines synthesis of targeted pharmaceutical intermediates.

Application

3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione serves as a versatile building block for the synthesis of isoindoline-based heterocyclic scaffolds prevalent in medicinal chemistry. The pendant amino group enables direct functionalization, while the diketone moiety supports efficient cyclizations and metal-catalyzed couplings. Bench-stable and compatible with standard purification protocols, it facilitates rapid access to complex architectures in API discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H361-H373
Precautionary Statements : P260-P280-P405-P501

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Computational Chemistry Data

  • TPSA   92.5
  • LogP   -0.7383
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   1

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