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CS-W001157 4
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5-(Methoxymethyl)furan-2-carbaldehyde

  • CAS No. 1917-64-2

  • Cat. No. CS-0150190
  • Purity≥95%
  • MDL No.MFCD02253954

*For research and further manufacturing use only, not for direct human use.

5-(Methoxymethyl)furan-2-carbaldehyde|CS-0150190

Structure of 1917-64-2

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General Information

  • CAS No. 1917-64-2
  • Cat. No. CS-0150190
  • Purity ≥95%
  • MDL No. MFCD02253954
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₃
  • Molecular Weight 140.14
  • Synonym(s) 5-(Methoxymethyl)-2-furaldehyde
  • SMILES COCC1=CC=C(C=O)O1

Description

5-(Methoxymethyl)furan-2-carbaldehyde features a furan ring with a formyl group at C2 and a methoxymethyl substituent at C5, combining electrophilic reactivity with enhanced solubility. This bifunctional scaffold integrates readily into heterocyclic synthesis, enabling efficient access to complex molecular architectures under standard conditions.

Application

5-(Methoxymethyl)furan-2-carbaldehyde serves as a versatile synthon in heterocyclic synthesis, enabling efficient access to functionalized furan derivatives. The aldehyde group facilitates nucleophilic additions and condensation reactions, while the methoxymethyl substituent offers orthogonal protection and mild deprotection conditions. Its stability under standard reaction protocols and compatibility with diverse functional groups make it a practical building block for medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      D-Fructose|CS-0008532
      57-48-7
    • ~24%
    • 5-Hydroxymethylfurfural, ≥99%|CS-1268396
      67-47-0
    • In-stock
      5-(Methoxymethyl)furan-2-carbaldehyde|CS-0150190
      1917-64-2

    References

    • Green Chemistry, , vol. 14, # 6 p. 1593 - 1596
  • Route2

    References

    • Liu, Ruliang; Chen, Jinzhu; Huang, Xing; Chen, Limin; Ma, Longlong; Li, Xinjun Green Chemistry, 2013 , vol. 15, # 10 p. 2895 - 2903
  • Route3

    References

    • WO2012/91570 A1, ; Page/Page column 13 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H303-H313-H333
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.44
  • LogP   1.2385
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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