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Structure of 1914946-33-0
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Ethyl 5-bromoisoxazole-3-carboxylate features a brominated isoxazole core that enables direct functionalization in cross-coupling reactions. The ethyl ester group provides enhanced solubility and reactivity, while the electron-deficient heterocycle facilitates nucleophilic substitution. This bench-stable reagent integrates efficiently into synthetic sequences requiring regioselective halogenation or transition-metal-catalyzed transformations.
Ethyl 5-bromoisoxazole-3-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the 5-position via palladium-catalyzed cross-coupling. The bromine moiety exhibits high reactivity in Suzuki, Stille, and Negishi reactions, while the isoxazole core provides excellent stability under standard reaction conditions. Its ethyl ester group allows for selective transformations, facilitating downstream derivatization in medicinal chemistry and agrochemical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: