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CS-W001157 4
Total: USD 88.00

2,3-Dihydro-1-benzofuran-2-carboxylic acid

  • CAS No. 1914-60-9

  • Cat. No. CS-W001099
  • Molecule weight164.16
  • Purity≥98%
  • MDL No.MFCD03086168

*For research and further manufacturing use only, not for direct human use.

2,3-Dihydro-1-benzofuran-2-carboxylic acid|CS-W001099

Structure of 1914-60-9

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General Information

  • CAS No. 1914-60-9
  • Cat. No. CS-W001099
  • Purity ≥98%
  • MDL No. MFCD03086168
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈O₃
  • Molecular Weight 164.16
  • Synonym(s) 2,3-dihydrobenzofuran-2-carboxylic acid
  • SMILES O=C(O)C1CC2=CC=CC=C2O1

Description

This benzofuran-based carboxylic acid features a fused bicyclic core with enhanced stability and solubility in polar organic solvents. The dihydrobenzofuran scaffold provides a rigid, electron-rich platform ideal for coupling reactions and integration into bioactive scaffolds.

Application

2,3-Dihydro-1-benzofuran-2-carboxylic acid serves as a versatile scaffold in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions under standard conditions. The dihydrobenzofuran core exhibits good bench stability and functional group tolerance, supporting diverse transformations in synthetic workflows. This compound functions as a key building block for the construction of pharmacologically relevant scaffolds in drug discovery programs.

Synthesis

  • Route1

    References

    • US2005/54630 A1, ; Page/Page column 42 ; US 20050054630 A1
  • Route2

    References

    • Journal of Heterocyclic Chemistry, , vol. 24, # 2 p. 495 - 496
  • Route3
    • null|null
      90-02-8
    • ~%
    • In-stock
      2,3-Dihydro-1-benzofuran-2-carboxylic acid|CS-W001099
      1914-60-9

    References

    • Journal of Heterocyclic Chemistry, , vol. 24, # 2 p. 495 - 496

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.0747
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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