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CS-W001157 4
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2-Chloro-3-(trifluoromethyl)pyrazine

  • CAS No. 191340-90-6

  • Cat. No. CS-0043159
  • Purity≥97%
  • MDL No.MFCD21602140

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-(trifluoromethyl)pyrazine|CS-0043159

Structure of 191340-90-6

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General Information

  • CAS No. 191340-90-6
  • Cat. No. CS-0043159
  • Purity ≥97%
  • MDL No. MFCD21602140
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂ClF₃N₂
  • Molecular Weight 182.53
  • Synonym(s) Pyrazine,2-chloro-3-(trifluoroMethyl)
  • SMILES FC(F)(F)C1=C(Cl)N=CC=N1

Description

2-Chloro-3-(trifluoromethyl)pyrazine is a heterocyclic compound featuring a pyrazine core with orthogonal electron-withdrawing substituents. The chlorine and trifluoromethyl groups confer enhanced reactivity in cross-coupling processes, while the fused ring system provides rigidity and stability under standard conditions. This combination enables efficient incorporation into complex molecular architectures.

Application

2-Chloro-3-(trifluoromethyl)pyrazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chlorine substituent and electron-deficient pyrazine core. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the molecule exhibits excellent bench stability and compatibility with common protecting groups. Its defined reactivity profile facilitates efficient construction of heterocyclic scaffolds found in pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.1488
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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