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CS-W001157 4
Total: USD 88.00

Cholesterol absorption inhibitor 1

  • CAS No. 190595-65-4

  • Cat. No. CS-0140351
  • Purity≥98%
  • MDL No.MFCD13185976

*For research and further manufacturing use only, not for direct human use.

Cholesterol absorption inhibitor 1|CS-0140351

Structure of 190595-65-4

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General Information

  • CAS No. 190595-65-4
  • Cat. No. CS-0140351
  • Purity ≥98%
  • MDL No. MFCD13185976
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₁H₂₅F₂NO₃
  • Molecular Weight 497.53
  • Synonym(s) None
  • SMILES O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(OCC4=CC=CC=C4)C=C3)[C@H]1CCC(C5=CC=C(F)C=C5)=O

Description

Cholesterol absorption inhibitor 1 is a potent, selective agent that disrupts intestinal cholesterol uptake. This compound integrates into membrane microdomains to interfere with NPC1L1-mediated transport, offering a targeted approach to modulate systemic cholesterol levels without affecting bile acid synthesis.

Application

Cholesterol absorption inhibitor 1 serves as a well-characterized tool compound for studying intestinal cholesterol uptake. It functions as a potent, selective inhibitor of the Niemann-Pick C1-Like 1 (NPC1L1) protein, enabling research into lipid homeostasis and related metabolic pathways. Its robust bench stability and consistent activity in cell-based assays facilitate reliable screening and mechanistic studies in preclinical development.

Synthesis

  • Route1
    • null|null
      1206694-77-0
    • ~85%
    • In-stock
      Cholesterol absorption inhibitor 1|CS-0140351
      190595-65-4

    References

    • Sova, Matej; Mravljak, Janez; Kovac, Andreja; Pecar, Slavko; Casar, Zdenko; Gobec, Stanislav Synthesis, 2010 , # 20 art. no. P07810SS, p. 3433 - 3438
  • Route2
    • null|null
      352-13-6
    • null|null
      204589-84-4
    • ~38%
    • In-stock
      Cholesterol absorption inhibitor 1|CS-0140351
      190595-65-4

    References

    • KRKA Patent: EP1953140 A1, 2008 ; Location in patent: Page/Page column 16 ;
  • Route3
    • null|null
      181705-93-1
    • null|null
      204589-84-4
    • ~%
    • In-stock
      Cholesterol absorption inhibitor 1|CS-0140351
      190595-65-4

    References

    • Journal of Medicinal Chemistry, , vol. 41, # 6 p. 973 - 980

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.61
  • LogP   6.911
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   9

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