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CS-W001157 4
Total: USD 88.00

4-Phenylpyridin-2-ol

  • CAS No. 19006-81-6

  • Cat. No. CS-0188209
  • Purity≥98%
  • MDL No.MFCD07437954

*For research and further manufacturing use only, not for direct human use.

4-Phenylpyridin-2-ol|CS-0188209

Structure of 19006-81-6

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General Information

  • CAS No. 19006-81-6
  • Cat. No. CS-0188209
  • Purity ≥98%
  • MDL No. MFCD07437954
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉NO
  • Molecular Weight 171.20
  • Synonym(s) None
  • SMILES O=C1C=C(C2=CC=CC=C2)C=CN1

Description

4-Phenylpyridin-2-ol features a rigid, planar architecture integrating a pyridinol core with an aryl substituent, enabling strong π-stacking and metal chelation. This structural motif delivers enhanced stability in coordination environments while maintaining solubility in common organic solvents. The phenyl ring enhances electron delocalization, supporting applications in ligand design and functional materials.

Application

4-Phenylpyridin-2-ol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through established coupling and functionalization reactions. Its phenolic hydroxyl group offers reliable derivatization potential, while the pyridin-2-ol core provides strong metal-chelating ability and favorable solubility. The molecule exhibits bench stability and compatibility with standard purification methods, facilitating integration into multi-step synthetic sequences for API development.

Synthesis

  • Route1

    References

    • Dales, Natalie; Fonarev, Julia; Fu, Jianmin; Hou, Duanjie; Kamboj, Rajender; Kodumuru, Vishnumurthy; Pokrovskaia, Natalia; Raina, Vandna; Sun, Shaoyi; Zhang, Zaihui Patent: US2009/156615 A1, 2009 ; Location in patent: Page/Page column 17 ; US 20090156615 A1
  • Route2
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    • In-stock
      4-Phenylpyridin-2-ol|CS-0188209
      19006-81-6

    References

    • Organic Letters, , vol. 3, # 26 p. 4263 - 4265
  • Route3

    References

    • Organic Letters, , vol. 3, # 26 p. 4263 - 4265

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.4542
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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