Lot numbers can be found on the outside label of a product:
Quinazoline-2,4-diamine
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CAS No. 1899-48-5
- Cat. No. CS-W022949
- Purity≥97%
- MDL No.MFCD00236032
*For research and further manufacturing use only, not for direct human use.
Structure of 1899-48-5
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General Information
- CAS No. 1899-48-5
- Cat. No. CS-W022949
- Purity ≥97%
- MDL No. MFCD00236032
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₈N₄
- Molecular Weight 160.18
- Synonym(s) 2,4-Quinazolinediamine
- SMILES NC1=NC2=CC=CC=C2C(N)=N1
Description
Quinazoline-2,4-diamine serves as a core scaffold in medicinal chemistry, offering a rigid, electron-rich platform for targeted drug design. This heterocyclic diamine integrates readily into kinase inhibitors and bioactive molecules, leveraging its ability to form key hydrogen bonds within protein binding pockets. Its bench-stable nature supports reliable use in synthetic workflows and structure-activity studies.
Application
Quinazoline-2,4-diamine serves as a key heterocyclic building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive scaffolds. Its two adjacent amine groups offer high reactivity for diverse functionalization—particularly in amidation, alkylation, and coupling reactions—facilitating rapid diversification. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for iterative library synthesis and process-scale applications.
Synthesis
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Route1
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In-stock
607-68-1 - ~%
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In-stock
1899-48-5
References
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Journal of the American Chemical Society, , vol. 57, p. 1068
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Route2
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2042-37-7 -
In-stock
50-01-1 - ~64%
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In-stock
1899-48-5
References
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Yang, Xiaobo; Liu, Hongxia; Futa, Hua; Qiao, Renzhong; Jiang, Yuyang; Zhao, Yufen Synlett, 2010 , # 1 p. 101 - 106
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Route3
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394-47-8
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124-46-9
- ~76%
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In-stock
1899-48-5
References
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Chao, Bo; Tong, Xian-Kun; Tang, Wei; Li, De-Wen; He, Pei-Lan; Garcia, Jean-Michel; Zeng, Li-Min; Gao, An-Hui; Yang, Li; Li, Jia; Nan, Fa-Jun; Jacobs, Michael; Altmeyer, Ralf; Zuo, Jian-Ping; Hu, You-Hong Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3135 - 3143
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H319
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Precautionary Statements : P264-P270-P280-P330-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 77.82
- LogP 0.7942
- H_Acceptors 4
- H_Donors 2
- Rotatable_Bonds 0
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