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CS-W001157 4
Total: USD 88.00

4-Methoxyphthalic acid

  • CAS No. 1885-13-8

  • Cat. No. CS-W008989
  • Purity≥97%
  • MDL No.MFCD00094739

*For research and further manufacturing use only, not for direct human use.

4-Methoxyphthalic acid|CS-W008989

Structure of 1885-13-8

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General Information

  • CAS No. 1885-13-8
  • Cat. No. CS-W008989
  • Purity ≥97%
  • MDL No. MFCD00094739
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈O₅
  • Molecular Weight 196.16
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=C(OC)C=C1C(=O)O

Description

4-Methoxyphthalic acid features a para-methoxy-substituted aromatic core, enhancing solubility and electronic modulation in synthetic applications. This bench-stable diacid integrates readily into polymer backbones and coordination complexes, offering robust reactivity under standard conditions.

Application

4-Methoxyphthalic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of functionalized aromatic scaffolds through standard esterification, amidation, and coupling reactions. Its ortho-dicarboxylic acid core provides excellent reactivity for metal coordination and cyclization processes, while the methoxy substituent offers moderate electron donation and enhanced solubility. Bench-stable and readily purified by recrystallization, it functions reliably in the synthesis of heterocycles, pharmaceutical intermediates, and specialty polymers.

Synthesis

  • Route1
    • null|null
      22895-19-8
    • ~10%
    • In-stock
      4-Methoxyphthalic acid|CS-W008989
      1885-13-8

    References

    • WO2008/44029 A1, ; Page/Page column 203 ;
  • Route2
    • null|null
      201230-82-2
    • In-stock
      3-Methoxybenzoic acid|CS-D1416
      586-38-9
    • ~79%
    • In-stock
      4-Methoxyphthalic acid|CS-W008989
      1885-13-8

    References

    • Journal of the American Chemical Society, , vol. 130, # 43 p. 14082 - 14083
  • Route3
    • In-stock
      4-Hydroxyphthalic acid|CS-D0572
      610-35-5
    • null|null
      74-88-4
    • ~51%
    • In-stock
      4-Methoxyphthalic acid|CS-W008989
      1885-13-8

    References

    • EP1214325 B1, ; Page/Page column 27-28 ; EP 1214325 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.83
  • LogP   1.0916
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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