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Structure of 188057-56-9
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4-Chloro-2-iodopyridin-3-ol features a halogenated pyridinol scaffold with complementary reactivity at the 2- and 4-positions. This bench-stable compound enables direct coupling strategies in cross-coupling reactions, particularly in late-stage functionalization of heterocyclic architectures. The electron-deficient pyridine ring enhances regioselective metal-catalyzed transformations, while the iodide serves as a high-efficiency handle for palladium-mediated bond formation.
4-Chloro-2-iodopyridin-3-ol serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. The iodo group facilitates palladium-catalyzed coupling reactions with broad functional group tolerance, while the chloro and hydroxyl substituents provide orthogonal reactivity for sequential transformations. This compound exhibits good bench stability and is readily purified by crystallization, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: