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CS-W001157 4
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6-Bromo-2-iodopyridin-3-ol

  • CAS No. 188057-35-4

  • Cat. No. CS-0156781
  • Purity≥98%
  • MDL No.MFCD11977407

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-iodopyridin-3-ol|CS-0156781

Structure of 188057-35-4

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General Information

  • CAS No. 188057-35-4
  • Cat. No. CS-0156781
  • Purity ≥98%
  • MDL No. MFCD11977407
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrINO
  • Molecular Weight 299.89
  • Synonym(s) 6-Bromo-2-iodo-3-pyridinol
  • SMILES C1=CC(=NC(=C1O)I)Br

Description

6-Bromo-2-iodopyridin-3-ol features a pyridin-3-ol core bearing bromo and iodo substituents at the 6- and 2-positions, respectively. This electron-deficient heterocycle enables direct functionalization in cross-coupling reactions. The phenolic hydroxyl group offers a site for derivatization or metal coordination. Bench-stable under standard conditions, this compound serves as a key building block in medicinal chemistry and materials synthesis.

Application

6-Bromo-2-iodopyridin-3-ol serves as a versatile building block for late-stage functionalization and cross-coupling reactions in medicinal chemistry. The molecule combines bromo and iodo substituents at electronically distinct positions on the pyridine core, enabling sequential or selective Pd-catalyzed transformations. Its phenolic hydroxyl group provides a handle for derivatization or metal complexation, while the halogenated framework ensures compatibility with standard Suzuki, Stille, and Negishi coupling protocols. Bench-stable and readily purified by crystallization, it functions reliably in multi-step synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.1543
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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