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CS-W001157 4
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2-(2-Methoxyphenoxy)acetic acid

  • CAS No. 1878-85-9

  • Cat. No. CS-0106585
  • Purity≥98%
  • MDL No.MFCD00014352

*For research and further manufacturing use only, not for direct human use.

2-(2-Methoxyphenoxy)acetic acid|CS-0106585

Structure of 1878-85-9

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General Information

  • CAS No. 1878-85-9
  • Cat. No. CS-0106585
  • Purity ≥98%
  • MDL No. MFCD00014352
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₄
  • Molecular Weight 182.17
  • Synonym(s) Guaiacoxyacetic acid
  • SMILES O=C(O)COC1=CC=CC=C1OC

Description

This compound features a methoxy-substituted phenoxy moiety linked to a carboxylic acid via an acetyl spacer. The electron-donating methoxy group enhances solubility and modulates electronic properties, while the pendant acid enables derivatization or salt formation. Designed for use in synthetic intermediates, this structure integrates readily into bioactive molecule scaffolds requiring polar, aromatic functionality under standard conditions.

Application

2-(2-Methoxyphenoxy)acetic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methoxyphenyl ether functionality enables efficient coupling reactions, while the carboxylic acid group facilitates derivatization via esterification, amidation, or salt formation. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for use in iterative synthetic sequences and medicinal chemistry campaigns.

Synthesis

  • Route1
    • Methyl 2-(2-methoxyphenoxy)acetate|CS-0361725
      38768-62-6
    • ~90%
    • In-stock
      2-(2-Methoxyphenoxy)acetic acid|CS-0106585
      1878-85-9

    References

    • Mirk, Daniela; Waldvogel, Siegfried R. Tetrahedron Letters, 2004 , vol. 45, # 42 p. 7911 - 7914
  • Route2
    • Ethyl 2-(2-methoxyphenoxy)acetate|CS-D0564
      13078-21-2
    • ~98%
    • In-stock
      2-(2-Methoxyphenoxy)acetic acid|CS-0106585
      1878-85-9

    References

    • Buendia, Julien; Mottweiler, Jakob; Bolm, Carsten Chemistry - A European Journal, 2011 , vol. 17, # 49 p. 13877 - 13882
  • Route3
    • Guaiacol Guaifenesin Impurity|CS-0229801
      90-05-1
    • null|null
      79-11-8
    • ~76%
    • In-stock
      2-(2-Methoxyphenoxy)acetic acid|CS-0106585
      1878-85-9

    References

    • Strijdonck, Gino P. F. van; Haare, John A. E. H. van; Hoenen, Paulus J.M.; Schoor, Roger C. G. M. van den; Feiters, Martinus C.; et al. Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1997 , p. 449 - 462

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.1586
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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