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CS-W001157 4
Total: USD 88.00

2-(Propan-2-yloxy)pyridin-3-amine

  • CAS No. 187654-86-0

  • Cat. No. CS-0249005
  • Molecule weight152.19
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Propan-2-yloxy)pyridin-3-amine|CS-0249005

Structure of 187654-86-0

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General Information

  • CAS No. 187654-86-0
  • Cat. No. CS-0249005
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₂O
  • Molecular Weight 152.19
  • Synonym(s) 3-AMINO-2-(ISO-PROPOXY)PYRIDINE
  • SMILES NC1=C(OC(C)C)N=CC=C1

Description

2-(Propan-2-yloxy)pyridin-3-amine features a pyridin-3-amine core decorated with a tert-butoxy group at the ortho position, enhancing solubility and stability. This bench-stable scaffold integrates readily into transition metal-catalyzed coupling reactions, enabling efficient access to functionalized heterocycles in medicinal chemistry and materials synthesis.

Application

2-(Propan-2-yloxy)pyridin-3-amine serves as a versatile pyridine-based building block for medicinal chemistry and catalyst development. Its ortho-amino functionality enables direct metallation or coupling reactions, while the tert-butoxy group provides steric protection and enhanced solubility. The molecule exhibits excellent bench stability and facilitates efficient functionalization in standard cross-coupling and electrophilic substitution protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.451
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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