Lot numbers can be found on the outside label of a product:
3,5-Dimethoxypyridine
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CAS No. 18677-48-0
- Cat. No. CS-W001486
- Purity≥95%
- MDL No.MFCD01646188
*For research and further manufacturing use only, not for direct human use.
Structure of 18677-48-0
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General Information
- CAS No. 18677-48-0
- Cat. No. CS-W001486
- Purity ≥95%
- MDL No. MFCD01646188
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₉NO₂
- Molecular Weight 139.15
- Synonym(s) 3,5-dimethoxy-pyridine
- SMILES COC1=CC(OC)=CN=C1
Description
3,5-Dimethoxypyridine features two methoxy groups positioned at the 3- and 5-positions of the pyridine ring, creating a symmetric, electron-rich heteroaromatic scaffold. This configuration enhances solubility in organic solvents while maintaining bench-stable handling characteristics. The compound serves as a key building block in medicinal chemistry for constructing bioactive molecules, particularly where moderate electron density and controlled polarity are required.
Application
3,5-Dimethoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through cross-coupling and electrophilic substitution reactions. Its ortho-dimethoxy substitution pattern enhances solubility and facilitates functionalization at the 2- and 6-positions, while maintaining bench stability and ease of purification. The molecule functions effectively as a synthetic handle in transition-metal-catalyzed transformations, supporting the development of diverse API candidates.
Synthesis
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Route1
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124-41-4 -
In-stock
84476-99-3 - ~93%
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In-stock
18677-48-0
References
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BRISTOL-MYERS SQUIBB COMPANY Patent: WO2007/30582 A2, 2007 ; Location in patent: Page/Page column 88 ; WO 2007/030582 A2
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Route2
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124-41-4
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71902-33-5
- ~56%
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In-stock
18677-48-0
References
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GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley Patent: WO2013/102145 A1, 2013 ; Location in patent: Paragraph 0315 ;
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Route3
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2457-47-8 - ~59%
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In-stock
18677-48-0
References
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Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto Tetrahedron, 1985 , vol. 41, # 7 p. 1373 - 1384
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 31.35
- LogP 1.0988
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 2
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