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CS-W001157 4
Total: USD 88.00

5-Bromo-2,3-difluorophenol

  • CAS No. 186590-26-1

  • Cat. No. CS-W015186
  • Purity≥96%
  • MDL No.MFCD01631350

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,3-difluorophenol|CS-W015186

Structure of 186590-26-1

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General Information

  • CAS No. 186590-26-1
  • Cat. No. CS-W015186
  • Purity ≥96%
  • MDL No. MFCD01631350
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrF₂O
  • Molecular Weight 208.99
  • Synonym(s) Bromodifluorophenol5
  • SMILES OC1=CC(Br)=CC(F)=C1F

Description

5-Bromo-2,3-difluorophenol delivers a trifunctional aromatic scaffold with orthogonal reactivity. The bromine at C5 enables palladium-catalyzed cross-coupling, while the adjacent difluoro substitution enhances metabolic stability and modulates electron density. This bench-stable phenolic platform integrates readily into bioactive molecule design, offering precise control over lipophilicity and electronic profile in medicinal chemistry applications.

Application

5-Bromo-2,3-difluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of bromo- and difluoro-substituted aryl motifs. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient construction of complex heterocycles and biaryl scaffolds. The presence of orthogonal functional groups supports sequential derivatization, making it a practical choice for multi-step synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.4329
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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