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CS-W001157 4
Total: USD 88.00

2-((Difluoromethyl)sulfonyl)benzo[d]thiazole

  • CAS No. 186204-66-0

  • Cat. No. CS-0159031
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-((Difluoromethyl)sulfonyl)benzo[d]thiazole|CS-0159031

Structure of 186204-66-0

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General Information

  • CAS No. 186204-66-0
  • Cat. No. CS-0159031
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₂NO₂S₂
  • Molecular Weight 249.26
  • Synonym(s) 2-Benzo[d]thiazolyl difluoromethylsulfone
  • SMILES O=S(C1=NC2=CC=CC=C2S1)(C(F)F)=O

Description

This difluoromethylsulfonyl-substituted benzo[d]thiazole features a strongly electron-deficient heterocyclic core, enabling efficient coupling in cross-coupling reactions. The difluoromethylsulfonyl group enhances stability and modulates reactivity, facilitating direct functionalization of complex scaffolds under mild conditions.

Application

2-((Difluoromethyl)sulfonyl)benzo[d]thiazole serves as a versatile building block in medicinal chemistry, leveraging the strong electron-withdrawing nature of the difluoromethylsulfonyl group to modulate reactivity and metabolic stability. It functions effectively in cross-coupling reactions and facilitates late-stage functionalization due to its bench-stable, crystalline nature and compatibility with diverse reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   47.03
  • LogP   2.2926
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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