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CS-W001157 4
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(S)-N,N-Dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine

  • CAS No. 185449-80-3

  • Cat. No. CS-0031336
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-N,N-Dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine|CS-0031336

Structure of 185449-80-3

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General Information

  • CAS No. 185449-80-3
  • Cat. No. CS-0031336
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₁₈NO₂P
  • Molecular Weight 359.36
  • Synonym(s) (R)-N,N-Dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine
  • SMILES CN(C)P1OC2=[C@]([C@]3=C(C=CC=C4)C4=CC=C3O1)C5=C(C=CC=C5)C=C2

Application

(S)-N,N-Dimethyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine serves as a chiral phosphine ligand in transition metal-catalyzed cross-coupling reactions. Its rigid, fused bicyclic structure imparts high thermal stability and enhanced steric bulk, facilitating selective C–C bond formation. The dimethylamino group improves solubility and electronic tuning, enabling efficient palladium-catalyzed coupling processes with broad functional group tolerance and ease of purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.52
  • LogP   6.794
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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