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CS-W001157 4
Total: USD 88.00

2-(Chloromethyl)oxazole

  • CAS No. 185246-17-7

  • Cat. No. CS-D0011
  • Purity≥98%
  • MDL No.MFCD04114926

*For research and further manufacturing use only, not for direct human use.

2-(Chloromethyl)oxazole|CS-D0011

Structure of 185246-17-7

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General Information

  • CAS No. 185246-17-7
  • Cat. No. CS-D0011
  • Purity ≥98%
  • MDL No. MFCD04114926
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄ClNO
  • Molecular Weight 117.53
  • Synonym(s) 2-Chloromethyloxazole fandachem
  • SMILES ClCC1=NC=CO1

Description

2-(Chloromethyl)oxazole is a reactive heterocyclic building block featuring a chloromethyl group at the 2-position of an oxazole ring. This electrophilic site enables direct functionalization in nucleophilic substitution reactions, facilitating the integration of oxazole motifs into complex molecular architectures under mild conditions. The molecule exhibits high stability and compatibility with diverse reaction environments.

Application

2-(Chloromethyl)oxazole serves as a versatile building block in synthetic organic chemistry, enabling efficient introduction of chloromethyl functionality at the 2-position of oxazole. Its reactivity facilitates nucleophilic substitution and subsequent functionalization, particularly in the construction of heterocyclic scaffolds. The compound exhibits good bench stability and compatibility with common protecting groups, supporting its use in multi-step synthesis and medicinal chemistry campaigns.

Synthesis

  • Route1

    References

    • WO2007/34144 A1, ; Page/Page column 93 ; WO 2007/034144 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.03
  • LogP   1.4134
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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