2-Ethynylpyridin-3-amine

Name: 2-Ethynylpyridin-3-amine
Brand: ChemScene
Availability: InStock
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CAS No. 1849257-78-8
Cat. No. CS-0380350
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1849257-78-8

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Description

2-Ethynylpyridin-3-amine features a reactive alkyne group conjugated to a pyridyl amine, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and materials synthesis. This bench-stable compound integrates readily into functional architectures via click chemistry, offering high selectivity and yield under mild conditions.

Application

2-Ethynylpyridin-3-amine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted heterocycles via copper-catalyzed coupling reactions. Its terminal alkyne and primary amine functionalities offer orthogonal reactivity for click chemistry, Suzuki-Miyaura couplings, and amide bond formation. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

General Information

CAS No. 1849257-78-8
Cat. No. CS-0380350
Purity ≥97%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆N₂
Molecular Weight 118.14
Synonym(s) None
SMILES NC1=CC=CN=C1C#C

Computational Chemistry Data

TPSA 38.91
LogP 0.6451
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Alkyne

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Life Science Click Chemistry Reagents Alkyne

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

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2-Ethynylpyridin-3-amine

CAS No. 1849257-78-8

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