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CS-W001157 4
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7-Methyl-1H-indole-2-carboxylic acid

  • CAS No. 18474-60-7

  • Cat. No. CS-W005593
  • Purity≥97%
  • MDL No.MFCD00047168

*For research and further manufacturing use only, not for direct human use.

7-Methyl-1H-indole-2-carboxylic acid|CS-W005593

Structure of 18474-60-7

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General Information

  • CAS No. 18474-60-7
  • Cat. No. CS-W005593
  • Purity ≥97%
  • MDL No. MFCD00047168
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO₂
  • Molecular Weight 175.18
  • Synonym(s) 7-Methylindole-2-carboxyllic Acid
  • SMILES CC1=CC=CC2=C1NC(=C2)C(O)=O

Description

7-Methyl-1H-indole-2-carboxylic acid features a sterically hindered indole core with a methyl group at the 7-position and a carboxylic acid functional group at C2, enabling direct coupling reactions in synthetic peptide and pharmaceutical applications. This bench-stable derivative combines enhanced solubility with predictable reactivity, streamlining incorporation into complex molecular architectures under standard conditions.

Application

7-Methyl-1H-indole-2-carboxylic acid serves as a versatile building block for indole-based scaffolds in medicinal chemistry and materials science. Its carboxylic acid functionality enables direct coupling reactions, including amide formation and esterification, while the methyl group enhances metabolic stability. The molecule exhibits good bench stability and facilitates purification via recrystallization or column chromatography. It functions effectively in standard peptide coupling protocols and is compatible with a range of functional groups, making it suitable for modular synthesis of bioactive compounds and heterocyclic derivatives.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 46, # 19 p. 3957 - 3960

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.17452
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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