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CS-W001157 4
Total: USD 88.00

1-Boc-3-aminopiperidine

  • CAS No. 184637-48-7

  • Cat. No. CS-D0640
  • Purity≥98%
  • MDL No.MFCD01861219

*For research and further manufacturing use only, not for direct human use.

1-Boc-3-aminopiperidine|CS-D0640

Structure of 184637-48-7

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General Information

  • CAS No. 184637-48-7
  • Cat. No. CS-D0640
  • Purity ≥98%
  • MDL No. MFCD01861219
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₂
  • Molecular Weight 200.28
  • Synonym(s) tert-Butyl 3-Amino-1-piperidinecarboxylate
  • SMILES O=C(OC(C)(C)C)N(CCC1)CC1N

Description

1-Boc-3-aminopiperidine delivers a protected amine handle for efficient incorporation into diverse molecular architectures. The Boc group ensures stability during synthesis and facilitates selective deprotection under mild acidic conditions, enabling streamlined access to functionalized piperidine scaffolds in medicinal chemistry and target-oriented synthesis.

Application

1-Boc-3-aminopiperidine serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-containing scaffolds. The Boc group provides excellent stability and orthogonal protection, facilitating selective deprotection during multi-step synthesis. It functions reliably in amide couplings, reductive amination, and C–H functionalization reactions, offering broad compatibility with diverse reaction conditions. Its bench-stable nature and ease of purification make it ideal for high-throughput screening and API development workflows.

Synthesis

  • Route1
    • Benzyl 3-(tert-butoxycarbonylamino)piperidine-1-carboxylate|CS-W001566
      406213-47-6
    • ~%
    • In-stock
      1-Boc-3-aminopiperidine|CS-D0640
      184637-48-7

    References

    • EP1568699 A1, ; Page/Page column 41 ;
  • Route2

    References

    • EP1460061 A1, ; Page 6-7 ;
  • Route3

    References

    • US2005/159423 A1, ; Page/Page column 18 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.3446
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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