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CS-W001157 4
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Methyl 2-methyl-1H-indole-6-carboxylate

  • CAS No. 184150-96-7

  • Cat. No. CS-0042684
  • Purity≥95%
  • MDL No.MFCD18381247

*For research and further manufacturing use only, not for direct human use.

Methyl 2-methyl-1H-indole-6-carboxylate|CS-0042684

Structure of 184150-96-7

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General Information

  • CAS No. 184150-96-7
  • Cat. No. CS-0042684
  • Purity ≥95%
  • MDL No. MFCD18381247
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁NO₂
  • Molecular Weight None
  • Synonym(s) Methyl 2-methyl-indole-6-carboxylate
  • SMILES O=C(C1=CC2=C(C=C1)C=C(C)N2)OC

Description

Methyl 2-methyl-1H-indole-6-carboxylate features a sterically hindered indole core with a methyl group at the 2-position and a carboxylate ester at the 6-position. This configuration enhances solubility in organic solvents while maintaining stability under standard bench conditions. The molecule serves as a key scaffold for synthesizing bioactive indole derivatives, particularly in medicinal chemistry and natural product analogs.

Application

Methyl 2-methyl-1H-indole-6-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted indole scaffolds relevant to medicinal chemistry. The methyl ester group facilitates straightforward derivatization via hydrolysis or nucleophilic substitution, while the 2-methyl substituent enhances regioselectivity in electrophilic aromatic substitution. Its bench-stable nature and compatibility with standard coupling reactions make it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.09
  • LogP   2.26292
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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