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Structure of 183945-52-0
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3-Methyl-4-(trifluoromethoxy)aniline features a trifluoromethoxy group that enhances electron-withdrawal and metabolic stability, while the methyl substituent provides steric modulation. This combination imparts improved solubility and handling robustness under standard conditions, enabling efficient incorporation into pharmaceutical intermediates and functional materials.
3-Methyl-4-(trifluoromethoxy)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of heterocyclic scaffolds via standard coupling and cyclization protocols. Its trifluoromethoxy group confers enhanced metabolic stability and lipophilicity, while the aniline functionality facilitates facile derivatization through electrophilic substitution and amide formation. The compound exhibits good bench stability and is compatible with common purification methods, making it a practical choice for iterative synthetic campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: