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CS-W001157 4
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N4-Methylpyridine-3,4-diamine

  • CAS No. 1839-17-4

  • Cat. No. CS-0146043
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N4-Methylpyridine-3,4-diamine|CS-0146043

Structure of 1839-17-4

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General Information

  • CAS No. 1839-17-4
  • Cat. No. CS-0146043
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉N₃
  • Molecular Weight 123.16
  • Synonym(s) 3-Amino-4-(methylamino)pyridine
  • SMILES NC1=C(NC)C=CN=C1

Description

N4-Methylpyridine-3,4-diamine features a pyridine core functionalized with two amine groups and a methyl substituent at the nitrogen. This electron-rich scaffold enables direct incorporation into conjugated systems, serving as a key building block for advanced ligands and bioactive heterocycles. The methyl group enhances stability and modulates electronic properties.

Application

N4-Methylpyridine-3,4-diamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization reactions. Its pyridine core provides enhanced solubility and metabolic stability, while the N-methylated amine facilitates favorable pharmacokinetic properties. The compound exhibits excellent bench stability and compatibility with common functional groups, simplifying purification and downstream processing in multi-step syntheses.

Synthesis

  • Route1

    References

    • PFIZER PRODUCTS INC. Patent: WO2008/12622 A2, 2008 ; Location in patent: Page/Page column 55-56 ; WO 2008/012622 A2
  • Route2

    References

    • BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel Patent: WO2011/130661 A1, 2011 ;
  • Route3

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Nickolaus, Peter Patent: US2013/225609 A1, 2013 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.94
  • LogP   0.7055
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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