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CS-W001157 4
Total: USD 88.00

5-Amino-2-methoxypyridine-4-carboxylic acid

  • CAS No. 183741-91-5

  • Cat. No. CS-0050686
  • Molecule weight168.15
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Amino-2-methoxypyridine-4-carboxylic acid|CS-0050686

Structure of 183741-91-5

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General Information

  • CAS No. 183741-91-5
  • Cat. No. CS-0050686
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₃
  • Molecular Weight 168.15
  • Synonym(s) 5-Amino-2-methoxy-4-pyridinecarboxylic acid
  • SMILES COC1=CC(C(O)=O)=C(N)C=N1

Description

5-Amino-2-methoxypyridine-4-carboxylic acid features a pyridine core bearing complementary amino, methoxy, and carboxylic acid functionalities. This trifunctional scaffold enables direct integration into diverse synthetic pathways, particularly in medicinal chemistry and materials science applications. The electron-rich pyridine ring enhances reactivity in coupling reactions, while the carboxylic acid group provides a handle for derivatization under standard conditions.

Application

5-Amino-2-methoxypyridine-4-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its ortho-dicarboxylic acid motif enables direct coupling reactions, while the amino and methoxy groups offer orthogonal functionalization potential. The compound exhibits good bench stability and facilitates purification via crystallization or standard chromatography, making it well-suited for iterative synthesis workflows in API development and scaffold diversification.

Synthesis

  • Route1

    References

    • Rewcastle, Gordon W.; Denny, William A.; Winters, R. Thomas; Colbry, Norman L.; Showalter, H. D. Hollis Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 18 p. 2221 - 2226
  • Route2

    References

    • Journal of the Chemical Society - Perkin Transactions 1, , # 18 p. 2221 - 2226
  • Route3

    References

    • Journal of the Chemical Society - Perkin Transactions 1, , # 18 p. 2221 - 2226

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   85.44
  • LogP   0.3706
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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