Lot numbers can be found on the outside label of a product:
1-Boc-piperidine-4-Fmoc-amino-4-carboxylic acid
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CAS No. 183673-66-7
- Cat. No. CS-W002766
- Purity≥98%
- MDL No.MFCD01318741
*For research and further manufacturing use only, not for direct human use.
Structure of 183673-66-7
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General Information
- CAS No. 183673-66-7
- Cat. No. CS-W002766
- Purity ≥98%
- MDL No. MFCD01318741
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₂₆H₃₀N₂O₆
- Molecular Weight 466.53
- Synonym(s) N-FMOC-Amino-(4-N-BOC-piperidinyl)carboxylic acid
- SMILES O=C(NC1(C(O)=O)CCN(C(OC(C)(C)C)=O)CC1)OCC2C3=CC=CC=C3C4=CC=CC=C24
Description
1-Boc-piperidine-4-Fmoc-amino-4-carboxylic acid features a bifunctional scaffold integrating a protected piperidine ring with orthogonal handling groups. The Boc group ensures stability during synthesis, while the Fmoc moiety enables efficient, selective deprotection under mild conditions. This dual protection strategy facilitates precise incorporation into peptide chains and complex molecular architectures.
Application
1-Boc-piperidine-4-Fmoc-amino-4-carboxylic acid serves as a versatile bifunctional building block for the synthesis of constrained peptidomimetics and heterocyclic scaffolds. The Boc-protected amine enables orthogonal handling in multi-step syntheses, while the Fmoc group facilitates efficient solid-phase peptide coupling. The carboxylic acid functionality supports direct amidation or esterification, enabling integration into complex molecular architectures with high functional group tolerance and bench stability.
Synthesis
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References
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Bioorganic and Medicinal Chemistry, , vol. 21, # 18 p. 5694 - 5706
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Route2
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40064-34-4 - ~%
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In-stock
183673-66-7
References
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Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
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Route3
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In-stock
24424-99-5 - ~%
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In-stock
183673-66-7
References
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Journal of Organic Chemistry, , vol. 61, # 22 p. 7650 - 7651
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 105.17
- LogP 4.3794
- H_Acceptors 5
- H_Donors 2
- Rotatable_Bonds 4
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Key Words
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