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CS-W001157 4
Total: USD 88.00

N-Methylpyridin-3-amine

  • CAS No. 18364-47-1

  • Cat. No. CS-W005202
  • Purity≥98%
  • MDL No.MFCD01418130

*For research and further manufacturing use only, not for direct human use.

N-Methylpyridin-3-amine|CS-W005202

Structure of 18364-47-1

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General Information

  • CAS No. 18364-47-1
  • Cat. No. CS-W005202
  • Purity ≥98%
  • MDL No. MFCD01418130
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂
  • Molecular Weight 108.14
  • Synonym(s) N-Methyl-3-pyridinamine
  • SMILES CNC1=CC=CN=C1

Description

N-Methylpyridin-3-amine features a pyridine ring with a methylated nitrogen at the 3-position, delivering enhanced solubility and basicity compared to parent pyridine. This bench-stable derivative serves as a key scaffold in catalysis and medicinal chemistry, where its electron-rich nitrogen facilitates coordination in transition metal complexes and improves bioavailability in target-directed molecules.

Application

N-Methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its pyridine nitrogen and methylated amine functionality offer orthogonal reactivity for cross-coupling, functionalization, and metal coordination. The compound exhibits excellent bench stability, facilitates straightforward purification, and functions reliably in standard synthetic workflows for API development.

Synthesis

  • Route1
    • In-stock
      3-Bromopyridine|CS-0008362
      626-55-1
    • null|null
      74-89-5
    • ~93%
    • In-stock
      N-Methylpyridin-3-amine|CS-W005202
      18364-47-1

    References

    • Jiao, Jiao; Zhang, Xi-Ru; Chang, Ning-Hui; Wang, Jie; Wei, Jun-Fa; Shi, Xian-Ying; Chen, Zhan-Guo Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1180 - 1183
  • Route2
    • In-stock
      3-Chloropyridine|CS-W011253
      626-60-8
    • null|null
      74-89-5
    • ~92%
    • In-stock
      N-Methylpyridin-3-amine|CS-W005202
      18364-47-1

    References

    • Fors, Brett P.; Watson, Donald A.; Biscoe, Mark R.; Buchwald, Stephen L. Journal of the American Chemical Society, 2008 , vol. 130, # 41 p. 13552 - 13554
  • Route3
    • null|null
      462-08-8
    • null|null
      64-18-6
    • ~60%
    • In-stock
      N-Methylpyridin-3-amine|CS-W005202
      18364-47-1

    References

    • Tian, Zhongzhen; Li, Dongmei; Jiang, Zhaoxing; Li, Zhong 2011 , vol. 35, # 11 p. 628 - 629,2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.1233
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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