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Structure of 183610-73-3
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3-(Methylthio)pyridin-2-amine features a pyridine ring bearing a methylthio group at the 3-position and an amino substituent at the 2-position, creating a bifunctional scaffold with enhanced electron density. This arrangement enables efficient coupling in transition-metal-catalyzed reactions, particularly in Pd-mediated cross-couplings where the amine acts as a directing group. The molecule exhibits good stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, facilitating its use in synthetic workflows requiring precise functionalization.
3-(Methylthio)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds through palladium-catalyzed cross-coupling reactions. The methylthio group offers excellent stability under standard reaction conditions and facilitates selective transformations, while the pyridin-2-amine functionality provides a reliable handle for further derivatization via alkylation, acylation, or metal-catalyzed coupling. Its bench-stable nature and compatibility with common synthetic protocols make it well-suited for iterative synthesis campaigns in drug discovery.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: