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Structure of 1835759-78-8
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Aminooxy-PEG4-propargyl delivers a reactive alkyne handle flanked by a stable PEG4 spacer and a nucleophilic aminooxy group. This bifunctional reagent enables site-specific conjugation in bioorthogonal labeling workflows, combining efficient coupling with aqueous solubility and robust stability under physiological conditions.
Aminooxy-PEG4-propargyl serves as a versatile bifunctional linker for bioconjugation and polymer chemistry. The aminooxy group enables efficient oxime ligation with aldehydes or ketones under mild conditions, while the terminal alkyne facilitates copper-catalyzed (CuAAC) or strain-promoted (SPAAC) click reactions. The PEG4 spacer provides enhanced solubility and reduces steric hindrance, improving reaction efficiency. This compound offers excellent bench stability and ease of purification, making it well-suited for modular synthesis of functionalized biomolecules, targeted drug conjugates, and surface-functionalized materials.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362
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Lot numbers can be found on the outside label of a product: