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Aminooxy-PEG4-propargyl

  • CAS No. 1835759-78-8

  • Cat. No. CS-0114535
  • Molecule weight247.29
  • Purity≥97%
  • MDL No.MFCD29052160

*For research and further manufacturing use only, not for direct human use.

Aminooxy-PEG4-propargyl|CS-0114535

Structure of 1835759-78-8

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General Information

  • CAS No. 1835759-78-8
  • Cat. No. CS-0114535
  • Purity ≥97%
  • MDL No. MFCD29052160
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁NO₅
  • Molecular Weight 247.29
  • Synonym(s) None
  • SMILES NOCCOCCOCCOCCOCC#C

Description

Aminooxy-PEG4-propargyl delivers a reactive alkyne handle flanked by a stable PEG4 spacer and a nucleophilic aminooxy group. This bifunctional reagent enables site-specific conjugation in bioorthogonal labeling workflows, combining efficient coupling with aqueous solubility and robust stability under physiological conditions.

Application

Aminooxy-PEG4-propargyl serves as a versatile bifunctional linker for bioconjugation and polymer chemistry. The aminooxy group enables efficient oxime ligation with aldehydes or ketones under mild conditions, while the terminal alkyne facilitates copper-catalyzed (CuAAC) or strain-promoted (SPAAC) click reactions. The PEG4 spacer provides enhanced solubility and reduces steric hindrance, improving reaction efficiency. This compound offers excellent bench stability and ease of purification, making it well-suited for modular synthesis of functionalized biomolecules, targeted drug conjugates, and surface-functionalized materials.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   72.17
  • LogP   -0.4237
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   13

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