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CS-W001157 4
Total: USD 88.00

5-(Piperazin-1-yl)benzofuran-2-carboxamide

  • CAS No. 183288-46-2

  • Cat. No. CS-M1252
  • Purity≥98%
  • MDL No.MFCD20486139

*For research and further manufacturing use only, not for direct human use.

5-(Piperazin-1-yl)benzofuran-2-carboxamide|CS-M1252

Structure of 183288-46-2

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General Information

  • CAS No. 183288-46-2
  • Cat. No. CS-M1252
  • Purity ≥98%
  • MDL No. MFCD20486139
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅N₃O₂
  • Molecular Weight 245.28
  • Synonym(s) Vilazodone Intermediate 4
  • SMILES O=C(N)C1=CC2=CC(N3CCNCC3)=CC=C2O1

Description

This piperazinyl-substituted benzofuran scaffold integrates a hydrogen-bonding amide functionality with a basic piperazine ring, enabling versatile coordination in medicinal chemistry. The fused heterocyclic core provides rigidity and enhanced solubility, while the para-piperazinyl group offers tunable polarity for target engagement.

Application

5-(Piperazin-1-yl)benzofuran-2-carboxamide serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard amide coupling and functional group interconversions. Its benzofuran core provides structural rigidity and π-stacking potential, while the piperazinyl moiety offers hydrogen-bonding capacity and solubility enhancement. The compound exhibits bench stability and facilitates purification via standard chromatographic methods, making it well-suited for iterative synthesis campaigns in drug discovery programs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   71.5
  • LogP   0.9413
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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