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Bis(4-sulfobutyl)ether disodium

  • CAS No. 183278-30-0

  • Cat. No. CS-0137220
  • Molecule weight334.32
  • Purity≥97%
  • MDL No.MFCD28138233

*For research and further manufacturing use only, not for direct human use.

Bis(4-sulfobutyl)ether disodium|CS-0137220

Structure of 183278-30-0

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General Information

  • CAS No. 183278-30-0
  • Cat. No. CS-0137220
  • Purity ≥97%
  • MDL No. MFCD28138233
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆Na₂O₇S₂
  • Molecular Weight 334.32
  • Synonym(s) None
  • SMILES O=S(CCCCOCCCCS(=O)(O[Na])=O)(O[Na])=O

Description

Fmoc-Tyr(PO(NMe2)2)-OH is a useful derivative for the synthesis of phosphotyrosine-containing peptides by Fmoc SPPS [1]. As the side-chain phosphate group is fully protected, this derivative is compatible with all coupling methods.Regeneration of phosphotyrosine from the phosphodiamidate is effected by acid catalyzed hydrolysis using 90% aq. TFA. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] H. G. Chao, et al. (1995) J. Org. Chem., 60, 7710.

Application

Sodium 4,4'-oxybis(butane-1-sulfonate) serves as a robust, water-soluble sulfonate linker enabling efficient conjugation in aqueous-phase synthesis. Its bis-sulfonate functionality provides high solubility and stability under physiological conditions, facilitating clean coupling reactions with amine- and thiol-containing substrates. The molecule functions as a versatile building block for constructing bifunctional intermediates, particularly in the development of peptidomimetics and glycoconjugates, where orthogonality and ease of purification are critical.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   95.97
  • LogP   -0.5768
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   12

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