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Structure of 183278-30-0
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Fmoc-Tyr(PO(NMe2)2)-OH is a useful derivative for the synthesis of phosphotyrosine-containing peptides by Fmoc SPPS [1]. As the side-chain phosphate group is fully protected, this derivative is compatible with all coupling methods.Regeneration of phosphotyrosine from the phosphodiamidate is effected by acid catalyzed hydrolysis using 90% aq. TFA. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] H. G. Chao, et al. (1995) J. Org. Chem., 60, 7710.
Sodium 4,4'-oxybis(butane-1-sulfonate) serves as a robust, water-soluble sulfonate linker enabling efficient conjugation in aqueous-phase synthesis. Its bis-sulfonate functionality provides high solubility and stability under physiological conditions, facilitating clean coupling reactions with amine- and thiol-containing substrates. The molecule functions as a versatile building block for constructing bifunctional intermediates, particularly in the development of peptidomimetics and glycoconjugates, where orthogonality and ease of purification are critical.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: