6-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine

Name: 6-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine
Brand: ChemScene
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CAS No. 1832582-59-8
Cat. No. CS-0111661
Purity≥98%
MDL No.MFCD29921300

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6-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine|CS-0111661

Structure of 1832582-59-8

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General Information

CAS No. 1832582-59-8
Cat. No. CS-0111661
Purity ≥98%
MDL No. MFCD29921300
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆F₃N₅
Molecular Weight 229.16
Synonym(s) None
SMILES NC1=CC(C(F)(F)F)=C(N2N=CC=N2)N=C1

Description

6-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine features a trifluoromethyl group enhancing electron-withdrawal and metabolic stability, paired with a 1,2,3-triazole moiety enabling robust copper-catalyzed click chemistry. This combination delivers a bench-stable, moisture-tolerant scaffold ideal for constructing bioconjugates and functional materials under standard conditions.

Application

6-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles via CuAAC click chemistry. The triazole moiety offers excellent metabolic stability and hydrogen-bonding capacity, while the trifluoromethyl group enhances lipophilicity and binding affinity. Bench-stable and compatible with standard purification methods, it functions effectively in coupling reactions and scaffold diversification for targeted compound libraries.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 69.62
LogP 1.2633
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-(2H-1,2,3-Triazol-2-yl)-5-(trifluoromethyl)pyridin-3-amine

CAS No. 1832582-59-8

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