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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate

  • CAS No. 183170-69-6

  • Cat. No. CS-0011606
  • Purity≥96%
  • MDL No.MFCD15474944

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate|CS-0011606

Structure of 183170-69-6

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General Information

  • CAS No. 183170-69-6
  • Cat. No. CS-0011606
  • Purity ≥96%
  • MDL No. MFCD15474944
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃NO₃
  • Molecular Weight 229.32
  • Synonym(s) 1-tert-Butoxycarbonyl-4-(1-hydroxyethyl)piperidine; 4-(1-Hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-tert-Butyloxycarbonyl-4-hydroxyethyl-piperidine
  • SMILES OC(C1CCN(C(OC(C)(C)C)=O)CC1)C

Description

tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate features a chiral hydroxyethyl side chain attached to a piperidine core, enabling direct functionalization at the benzylic-like position. This bench-stable, moisture-tolerant building block integrates readily into medicinal chemistry campaigns requiring stereoselective transformations or downstream derivatization of nitrogen-containing heterocycles.

Application

tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate serves as a versatile chiral building block for medicinal chemistry, enabling direct access to piperidine-based scaffolds through mild deprotection or functionalization. The tertiary alcohol functionality offers controlled reactivity for oxidation, substitution, or coupling reactions, while the robust tert-butyl carbamate group ensures stability during multistep synthesis and facilitates purification via standard chromatographic methods.

Synthesis

  • Route1

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GINN, John David; SORCEK, Ronald John; TURNER, Michael Robert; WU, Di; WU, Frank Patent: WO2011/84985 A1, 2011 ; Location in patent: Page/Page column 85 ;
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    References

    • SMITH KLINE BEECHAM CORPORATION a corporation Patent: US2010/29650 A1, 2010 ; Location in patent: Page/Page column 77 ;
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    References

    • ELI LILLY AND COMPANY Patent: US2011/15199 A1, 2011 ; Location in patent: Page/Page column 6 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.0143
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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