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Total: USD 88.00

1-Cyclopropyl-1H-pyrazole-3-carbaldehyde

  • CAS No. 1823349-88-7

  • Cat. No. CS-0520777
  • Purity≥97%
  • MDL No.MFCD26520323
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

1-Cyclopropyl-1H-pyrazole-3-carbaldehyde|CS-0520777

Structure of 1823349-88-7

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Description

1-Cyclopropyl-1H-pyrazole-3-carbaldehyde features a cyclopropyl group attached to the pyrazole ring, enhancing metabolic stability and lipophilicity. The aldehyde functionality enables direct coupling in Ugi or Passerini reactions, while the electron-deficient pyrazole core supports efficient transition metal catalysis. This scaffold integrates readily into bioactive heterocycles for medicinal chemistry applications.

Application

1-Cyclopropyl-1H-pyrazole-3-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based heterocycles via standard condensation and coupling reactions. The aldehyde functionality facilitates rapid derivatization, including reductive amination and Wittig-type transformations, while the cyclopropyl group enhances metabolic stability and modulates lipophilicity. Bench-stable and compatible with common reaction conditions, it functions effectively in multi-step syntheses of bioactive scaffolds.

General Information

  • CAS No. 1823349-88-7
  • Cat. No. CS-0520777
  • Purity ≥97%
  • MDL No. MFCD26520323
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O
  • Molecular Weight 136.15
  • Synonym(s) 1-Cyclopropylpyrazole-3-carbaldehyde
  • SMILES O=CC1=NN(C2CC2)C=C1

Computational Chemistry Data

  • TPSA   34.89
  • LogP   1.0305
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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