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Structure of 182275-70-3
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2-Iodo-6-methoxypyridine is a bench-stable, moisture-tolerant heterocyclic building block featuring a reactive iodide at the 2-position and a methoxy group at the 6-position. This strategic substitution pattern enables efficient cross-coupling reactions in late-stage functionalization, particularly in palladium-catalyzed processes. The electron-deficient pyridine core enhances reactivity in nucleophilic displacement, facilitating rapid access to complex substituted pyridines under mild conditions.
2-Iodo-6-methoxypyridine serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl and heterocyclic architectures. The iodide group facilitates reliable Suzuki, Stille, and Negishi couplings under standard conditions, while the methoxy substituent provides orthogonal reactivity and enhanced solubility. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for medicinal chemistry and process-scale synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: