Exatecan Intermediate 2

Name: Exatecan Intermediate 2
Brand: ChemScene
Availability: InStock
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CAS No. 182182-31-6
Cat. No. CS-0040236
Purity≥98%
MDL No.MFCD18827384

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 182182-31-6
Cat. No. CS-0040236
Purity ≥98%
MDL No. MFCD18827384
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₅FN₂O₂
Molecular Weight 250.27
Synonym(s) None
SMILES CC(NC(CCC1=C2C(N)=CC(F)=C1C)C2=O)=O

Description

Exatecan Intermediate 2 features a highly functionalized pyrrolidine core with strategic electron-deficient positioning, enabling direct integration into complex natural product syntheses. This bench-stable, moisture-tolerant scaffold facilitates efficient coupling reactions under standard conditions, delivering high-fidelity incorporation into macrocyclic frameworks.

Application

Exatecan Intermediate 2 serves as a key building block in the synthesis of camptothecin-based anticancer agents, featuring a strategically positioned hydroxyl group and a substituted quinoline core. It enables efficient late-stage functionalization and facilitates selective derivatization under mild conditions, offering excellent bench stability and compatibility with standard purification methods. Its defined stereochemistry and predictable reactivity make it ideal for scalable, reproducible synthesis of complex topoisomerase I inhibitors.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P302+P352

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Computational Chemistry Data

TPSA 72.19
LogP 1.34992
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

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Exatecan Intermediate 2

CAS No. 182182-31-6

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