tert-Butyl (3R,4S)-4-amino-3-hydroxypiperidine-1-carboxylate

Name: tert-Butyl (3R,4S)-4-amino-3-hydroxypiperidine-1-carboxylate
Brand: ChemScene
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CAS No. 1821799-48-7
Cat. No. CS-0052935
Purity≥96%
MDL No.MFCD27978551

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tert-Butyl (3R,4S)-4-amino-3-hydroxypiperidine-1-carboxylate|CS-0052935

Structure of 1821799-48-7

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General Information

CAS No. 1821799-48-7
Cat. No. CS-0052935
Purity ≥96%
MDL No. MFCD27978551
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀N₂O₃
Molecular Weight 216.28
Synonym(s) (3R,4S)-1-Boc-4-amino-3-hydroxy-piperidine
SMILES CC(C)(C)OC(=O)N1CC[C@H](N)[C@H](O)C1

Description

tert-Butyl (3R,4S)-4-amino-3-hydroxypiperidine-1-carboxylate delivers a chiral piperidine scaffold with defined stereochemistry at C3 and C4. This bench-stable derivative features a hydroxyl group flanked by an amino function, enabling direct incorporation into complex molecular architectures. The tert-butyl carbamate protects the amine during synthetic manipulations while allowing straightforward deprotection under mild acidic conditions.

Application

tert-Butyl (3R,4S)-4-amino-3-hydroxypiperidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of bioactive piperidine derivatives. Its protected amine and hydroxyl groups enable orthogonal functionalization, while the (3R,4S) configuration supports predictable stereoselective transformations. The tert-butyl carbamate group provides bench stability and facilitates straightforward deprotection under mild acidic conditions, making it well-suited for iterative medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 75.79
LogP 0.3154
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

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tert-Butyl (3R,4S)-4-amino-3-hydroxypiperidine-1-carboxylate

CAS No. 1821799-48-7

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