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(Chloromethyl)triisopropoxysilane

  • CAS No. 18162-82-8

  • Cat. No. CS-0154179
  • Purity≥98%
  • MDL No.MFCD05664343

*For research and further manufacturing use only, not for direct human use.

(Chloromethyl)triisopropoxysilane|CS-0154179

Structure of 18162-82-8

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General Information

  • CAS No. 18162-82-8
  • Cat. No. CS-0154179
  • Purity ≥98%
  • MDL No. MFCD05664343
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₃ClO₃Si
  • Molecular Weight 254.83
  • Synonym(s) Chloromethyltriisopropoxysilane96
  • SMILES CC(C)O[Si](CCl)(OC(C)C)OC(C)C

Description

(Chloromethyl)triisopropoxysilane delivers a reactive chloromethyl group tethered to a triisopropoxysilyl moiety, enabling direct functionalization of surfaces and polymers. This moisture-tolerant silane integrates seamlessly into coupling reactions, offering stable anchoring through robust Si–O–Si linkages. The bulky isopropoxy groups enhance solubility and reduce hydrolytic cross-linking, facilitating controlled grafting under ambient conditions.

Application

(Chloromethyl)triisopropoxysilane serves as a stable, bench-ready silyl-protected chloromethyl building block, enabling efficient introduction of reactive CH₂Cl groups under mild conditions. Its triisopropoxysilyl moiety provides excellent functional group tolerance and facilitates straightforward deprotection with fluoride sources, making it ideal for iterative synthesis of complex molecules, including heterocyclic scaffolds and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   2.9783
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   7

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